cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (cpb). cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually igm or iga antibodies) that agglutinate in response to a decrease in body temperature. these disorders include cryoglobulinemia and cold hemagglutinin disease.immunoglobulin m aut...

Cold agglutinins are autoantibodies that agglutinate red blood cells at low temperatures, leading to haemagglutination and haemolysis. They are generally of no clinical significance. However, when people with cold agglutinins undergo cardiac operation with hypothermia and cold cardioplegia, they can experience complications. Thus, different perioperative management is required for such patients...

1. The metabolism of six purified and radioiodinated cold agglutinins has been studied in five patients with chronic cold haemagglutinin disease and in six normal controls. Two of the patients showed overt haemolysis at the time of this study and all had complement components adsorbed to the surface of their red cells. 2. The mean fractional catabolic rate (FCR) of the cold agglutinins, studied...

Cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (CPB). Cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually IgM or IgA antibodies) that agglutinate in response to a decrease in body temperature. These disorders include cryoglobulinemia and cold hemagglutinin disease.Immunoglobulin M aut...

Background: Malarial infection associated with common hematological abnormalities like anemia, Thrombocytopenia, Hemolytic anemia. Hemolytic anemia is due to occurrence of cold agglutinins. This study throws light on the prevalence of cold agglutinins in patients with malarial infection and their detection. Method: About 150 patients diagnosed as having Malaria by Peripheral smear, QBC for mala...

Immunologic studies performed in a case of autoimmune chronic hemolytic anemia with low titer cold agglutinins (1/16) demonstrated that the cold agglutinins corresponded to monoclonal IgG with anti-Pr specificity. This antibody had a large thermal amplitude, being active at 37 degrees C. These unusual characteristics may define a distinct subset of chronic cold agglutinin disease.

The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of beta-globulins, C'4 and C'3. The red cells of such patients are abnormally resistant to C' hemolysis by cold agglutinin. Normal red cells can be made equally resistant to C' hemolysis by incubation with cold agglutinin and normal ser...

Some of the properties of cold agglutinins in certain human sera have been listed in a recent review (1). The knowledge concerning these properties is based on studies of the phenomenon by various methods in serum or plasma from isolated cases of a large variety of conditions. With respect to the cold agglutinins in cases of primary atypical pneumonia, limited studies of certain aspects were re...